iphepha_ibhena

Iziphumo zoPhando zeZitofu ezimbini okanye ezine zePlatelet-rich Plasma kwi-Osteoarthritis Knee

Iinaliti ezimbini okanye ezine zeplasma ecebileyo yeplatelet kwidolo le-osteoarthritis ayizange iguqule i-synovial biomarkers, kodwa iphucule iziphumo zeklinikhi.

Ngokovavanyo lweengcali ezichaphazelekayo zoshishino, zithelekisa ii-injection ezimbini kunye ezine ze-intra-articular ze-plasma ecebileyo yeplatelet (PRP) ngokubhekiselele kutshintsho kwi-synovial cytokines kunye neziphumo zeklinikhi.Izigulane ze-125 ezine-knee osteoarthritis (OA) zafumana ii-injection ze-PRP rhoqo kwiiveki ze-6.Phambi kwenaliti ye-PRP nganye, iminqweno ye-synovial fluid yaqokelelwa ukuze kufundwe.Izigulane zahlulwa zibe zi-injection ezimbini okanye ezine ze-PRP ze-intra-articular (amaqela A kunye no-B, ngokulandelanayo).Utshintsho kwiimpawu ze-synovial biomarkers zifaniswa namanqanaba asisiseko kumaqela omabini, kwaye iziphumo zeklinikhi zavavanywa ukuya kutsho kunyaka omnye.

Izigulane ezingamashumi asithoba anesine ezigqibe ukuqokelela i-synovial fluid zifakwe kuvavanyo lokugqibela, i-51 kwiqela A kunye ne-43 kwiqela B. Kwakungekho nantlukwano kwiminyaka yobudala, isondo, i-index mass body (BMI), kunye ne-radiographic OA grade.Ubungakanani beplatelet ephakathi kunye nenani elimhlophe legazi elimhlophe kwi-PRP laliyi-430,000 / µL kunye ne-200 / µL, ngokulandelanayo. -4, IL-10, IL-13, kunye ne-IL-1RA) azizange zitshintshe, kwaye i-Factors yokukhula (TGF-B1, VEGF, PDGF-AA kunye ne-PDGF-BB) yayisisiseko kwaye phakathi kweeveki ze-6 kwiQela A kunye neeveki ze-18. kwiQela B.

Iziphumo zeklinikhi kumaqela omabini ziphuculwe kakhulu ukusuka kwiiveki ze-6, kubandakanywa ne-Visual Analog Scale (VAS), iMilinganiselo yeSiphumo esiNgxelo ngesigulane [iiPROM;I-Western Ontario kunye neMcMaster Universities Osteoarthritis (WOMAC) Index kunye neFomu emfutshane-12 (SF-12)], amanyathelo asekelwe ekusebenzeni [PBMs;ixesha lokuvuka (TUG), iimvavanyo ze-5 zokuhlala (5 × SST), kunye neemvavanyo zokuhamba ngomzuzu-3 (i-3-minute WT)]. Ekugqibeleni, i-2 okanye i-4 intra-articular injections ye-PRP nganye kwiiveki ze-6 emadolweni I-OA ayizange ibonise utshintsho kwi-synovial cytokines kunye nezinto zokukhula, kodwa iphinde yaphucula iziphumo zekliniki ukusuka kwiiveki ze-6 ukuya kwi-1 ngonyaka.


Ixesha lokuposa: Mar-03-2022