Iiplatelets, njengamaqhekeza eeseli ezivela kwi-bone marrow megakaryocytes, zibonakaliswa ngokungabikho kwe-nuclei.Iplatelet nganye ineendidi ezintathu zamasuntswana, ezizezi, α Granules, imizimba exineneyo kunye neelysosomes ezinobungakanani obahlukeneyo.Kubandakanya i-α I-granules zizityebi ngaphezu kwe-300 yeeprotheyini ezahlukeneyo, ezifana ne-vascular endothelial activating factor, i-leukocyte chemotactic factor, i-activating factor, ukulungiswa kwezicubu ezinxulumene ne-peptide ye-antibacterial, ebandakanyeka kwiinkqubo ezininzi ze-physiological and pathological, ezifana nokuphulukiswa kwesilonda. , i-angiogenesis kunye ne-anti infection immunity.
Umzimba oxineneyo uqulethe i-adenosine diphosphate (ADP), i-adenosine triphosphate (ATP), i-Ca2 +, i-Mg2 + kunye ne-5-hydroxytryptamine.I-Lysosomes iqulethe iindidi ze-sugar proteases, ezifana ne-glycosidases, i-proteases, iiprotheni ze-cationic kunye neeprotheni ezinomsebenzi we-bactericidal.Ezi GF zikhutshelwa egazini emva kokusebenza kweplatelet.
I-GF ibangela ukusabela kwe-cascade ngokuzibophelela ngeentlobo ezahlukeneyo ze-membrane receptors zeseli, kwaye ivule imisebenzi ethile kwinkqubo yokuhlaziywa kwezicubu.Okwangoku, i-GF efundwa kakhulu yi-platelet derived growth factor (PDGF) kunye nokuguqula ukukhula (TGF- β (TGF- β) , i-Vascular endothelial growth factor (VEGF), i-epidermal growth factor (EGF), i-fibroblast factor factor (FGF), I-CTGF kunye ne-insulin-efana ne-1 (IGF-1) i-GF inceda ukulungisa imisipha, i-tendon, i-ligament kunye nezinye izicubu ngokukhuthaza ukwanda kweeseli kunye nokwahlula, i-angiogenesis kunye nezinye iinkqubo, kwaye emva koko zidlala ngokuhambelanayo. indima.
Ukusetyenziswa kwe-PRP kwi-Vitiligo
I-Vitiligo, njengesifo esiqhelekileyo somzimba, kunye nomthamo wesifo solusu, sinefuthe elibi kwingqondo yezigulane kwaye zichaphazele kakhulu umgangatho wobomi bezigulane.Ukushwankathela, ukuvela kwe-vitiligo kuyisiphumo sokusebenzisana kwezinto zofuzo kunye nezinto ezisingqongileyo, ezibangela ukuba i-melanocytes yesikhumba ihlaselwe kwaye yonakaliswe yinkqubo yokuzimela.Okwangoku, nangona maninzi amayeza e-vitiligo, ukusebenza kwawo kunqabile, kwaye unyango oluninzi alunabungqina bamayeza asekwe kubungqina.Kwiminyaka yakutshanje, ngokuphononongwa okuqhubekayo kwe-pathogenesis ye-vitiligo, ezinye iindlela zonyango olutsha ziye zasetyenziswa rhoqo.Njengendlela esebenzayo yokunyanga i-vitiligo, i-PRP isetyenziswe ngokuqhubekayo.
Okwangoku, i-308 nm excimer laser kunye ne-311 nm imxinwa band ultraviolet (NB-UVB) kunye nobunye ubugcisa befototherapy ziya ziqondwa ngokwandayo ngokusebenza kwazo kwizigulana ezinevitiligo.Okwangoku, ukusetyenziswa kwe-autologous PRP subcutaneous injection ye-microneedle edityaniswe ne-phototherapy kwizigulane ezine-vitiligo ezizinzile zenze inkqubela enkulu.Abdelghani et al.Kufunyenwe kuphando lwabo ukuba i-autologous PRP subcutaneous microneedle injection idityaniswe ne-NB-UVB phototherapy inokunciphisa kakhulu ixesha lonyango lwe-vitiligo.
Khattab et al.zinyange izigulana ezine-vitiligo ezizinzile ezingekho segmental nge-308 nm excimer laser kunye ne-PRP, kwaye zafumana iziphumo ezilungileyo.Kwafunyaniswa ukuba indibaniselwano yezi zibini inokuphucula ngokufanelekileyo ireyithi ye-leucoplakia recolor, ukunciphisa ixesha lonyango, kwaye igweme ukusabela okungalunganga kokusetyenziswa kwexesha elide le-308 nm excimer laser irradiation.Ezi zifundo zibonisa ukuba i-PRP idityaniswe ne-phototherapy yindlela esebenzayo yonyango lwe-vitiligo.
Nangona kunjalo, u-Ibrahim kunye nezinye izifundo zicebisa ukuba i-PRP yodwa ayisebenzi kunyango lwe-vitiligo.UKadry et al.yenze uphando olulawulwa ngokungahleliwe kunyango lwe-vitiligo kunye ne-PRP edityaniswe ne-carbon dioxide dot matrix laser, kwaye yafumanisa ukuba i-PRP idityaniswe ne-carbon dioxide dot matrix laser kunye ne-PRP yodwa iphumelele umphumo omuhle wokuvelisa umbala.Phakathi kwabo, i-PRP idibene ne-carbon dioxide dot matrix laser yayinomphumo ongcono kakhulu wokuvelisa umbala, kwaye i-PRP yodwa yayifumene ukuveliswa kombala ophakathi kwi-leukoplakia.Impembelelo yokuvelisa umbala we-PRP yodwa yayingcono kune-carbon dioxide dot matrix laser yodwa kunyango lwe-vitiligo.
Umsebenzi odibeneyo kunye ne-PRP kuNyango lwe-Vitiligo
I-Vitiligo luhlobo oluthile lwesifo se-pigment disorder esibonakala ngokuncipha kwebala.Iindlela zonyango eziqhelekileyo ziquka unyango lweziyobisi, i-phototherapy okanye utyando, okanye ukudibanisa iindlela ezininzi zonyango.Kwizigulane ezine-vitiligo ezinzile kunye nefuthe elibi lonyango oluqhelekileyo, unyango lotyando lunokuba lungenelelo lokuqala.
Garg et al.isetyenziswe i-PRP njenge-agent yokumiswa kweeseli ze-epidermal, kwaye isebenzise i-Er: i-YAG laser ukugaya amabala amhlophe, aphumelele umphumo omuhle wonyango kunyango lwezigulane ezizinzileyo ze-vitiligo.Kolu phononongo, izigulane ezili-10 ezine-vitiligo ezizinzileyo zabhaliswa kwaye izilonda ezingama-20 zafunyanwa.Kwizilonda ze-20, izilonda ze-12 (i-60%) zibonise ukubuyiswa kwe-pigment epheleleyo, izilonda ze-2 (i-10%) zibonise ukubuyiswa kwe-pigment enkulu, izilonda ze-4 (i-20%) zibonise ukubuyiswa kwe-pigment ephakathi, kunye nezilonda ze-2 (10%) azibonakalisi ukuphuculwa okuphawulekayo.Ukubuyiswa kwemilenze, amadolo, ubuso kunye nentamo kubonakala kakhulu, ngelixa ukubuyiswa kwemilenze kubi.
UNimitha et al.kusetyenziswe ukumiswa kwe-PRP yeeseli ze-epidermal ukulungiselela ukumiswa kunye ne-phosphate buffer ukumiswa kweeseli ze-epidermal ukuthelekisa nokujonga ukubuyiswa kwe-pigment kwizigulane ezine-vitiligo ezinzile.Izigulane ezingama-21 ezizinzileyo zevitiligo zibandakanyiwe kwaye amachokoza amhlophe angama-42 afunyanwa.Ixesha eliqhelekileyo le-vitiligo laliyiminyaka eyi-4.5.Uninzi lwezigulana zibonise umjikelo omncinci ukuya kwi-oval discrete pigment recovery malunga neenyanga ezi-1-3 emva konyango.Ngethuba leenyanga ze-6 zokulandelelana, ukubuyiswa kwe-pigment ephakathi kwaba yi-75.6% kwiqela le-PRP kunye ne-65% kwiqela elingekho le-PRP.Umahluko wendawo yokubuyisela i-pigment phakathi kweqela le-PRP kunye neqela elingekho le-PRP lalibaluleke kakhulu.Iqela le-PRP libonise ukubuyiswa kwe-pigment engcono.Xa uhlalutya izinga lokubuyisela i-pigment kwizigulane ezine-vitiligo ye-segmental, akukho mmahluko obalulekileyo phakathi kweqela le-PRP kunye neqela elingekho le-PRP.
Ukusetyenziswa kwePRP kwiChloasma
I-Melasma luhlobo lwesifo solusu esifunyenweyo sobuso, esenzeka ikakhulu ebusweni babasetyhini abasoloko bevezwa kukukhanya kwe-ultraviolet kwaye banombala wolusu olunzulu.I-pathogenesis yayo ayizange icaciswe ngokupheleleyo, kwaye kunzima ukuyiphatha kwaye kulula ukuyibuyisela.Okwangoku, unyango lwe-chloasma luthatha indlela yonyango edibeneyo.Nangona i-injection engaphantsi kwe-PRP ineendlela ezahlukeneyo zonyango lwe-chloasma, ukusebenza kwezigulane akwanelisi kakhulu, kwaye kulula ukuphinda ubuyele emva kokuyeka unyango.Kwaye iziyobisi zomlomo ezifana ne-tranexamic acid kunye ne-glutathione zinokubangela ukuphazamiseka kwesisu, ukuphazamiseka komjikelo wokuya exesheni, intloko ebuhlungu, kunye nokubunjwa kwe-vein thrombosis enzulu.
Ukuphonononga unyango olutsha lwe-chloasma lukhokelo olubalulekileyo kuphando lwe-chloasma.Kuxelwa ukuba i-PRP inokuphucula kakhulu izilonda zesikhumba zezigulane ezine-melasma.Cay ı rl ı Et al.ingxelo yokuba umfazi oneminyaka engama-27 ubudala wafumana inaliti ye-microneedle engaphantsi kwe-PRP rhoqo ngeentsuku ze-15.Ekupheleni kwonyango lwe-PRP lwesithathu, kwabonwa ukuba indawo yokubuyisela i-epidermal pigment yayi> 80%, kwaye akuzange kubekho ukuphindaphinda kwiinyanga ze-6.USirithanabadeekul et al.isetyenziswe i-PRP yonyango lwe-chloasma ukwenza i-RCT engqongqo ngakumbi, eyaqinisekisa ngakumbi ukusebenza kwe-intracutaneous PRP injection yonyango lwe-chloasma.
Hofny et al.wasebenzisa indlela ye-immunohistochemical yokuqhuba i-TGF ngokusebenzisa i-injection ye-microneedle engaphantsi kwe-PRP kwizilonda zesikhumba zezigulane ezine-chloasma kunye neengxenye eziqhelekileyo- β Ukuthelekisa ukubonakaliswa kweprotheni kubonise ukuba ngaphambi kokuba unyango lwe-PRP, izilonda zesikhumba zezigulane ezine-chloasma kunye ne-TGF ezijikeleze izilonda zesikhumba, β Ukubonakaliswa kweprotheni kwakungaphantsi kakhulu kunesikhumba esiphilileyo (P <0.05).Emva konyango lwe-PRP, i-TGF yezilonda zesikhumba kwizigulane ezine-chloasma- β Ukubonakaliswa kweprotheni kwanda kakhulu.Le nto ibonisa ukuba umphumo wokuphucula i-PRP kwizigulane ze-chloasma unokufumaneka ngokunyusa i-TGF yezilonda zesikhumba- β Ukubonakaliswa kweprotheni kufezekisa umphumo wonyango kwi-chloasma.
I-Photoelectric Technology idityaniswe ne-Subcutaneous Injection ye-PRP yoNyango lwe-Chloasma
Ngophuhliso oluqhubekayo lweteknoloji ye-photoelectric, indima yayo kunyango lwe-chloasma iye yatsala ingqalelo ngakumbi nangakumbi yabaphandi.Okwangoku, iilaser ezisetyenziselwa ukunyanga i-chloasma ziquka i-Q-switched laser, i-lattice laser, ukukhanya okukhulu kwe-pulsed, i-cuprous bromide laser kunye namanye amanyathelo onyango.Umgaqo-siseko kukuba ukugqabhuka kokukhanya okukhethiweyo kwenzelwa amasuntswana e-melanin ngaphakathi okanye phakathi kwe-melanocytes ngokukhethwa kwamandla, kwaye umsebenzi we-melanocytes awusebenzi okanye uthintelwe ngamandla aphantsi kunye nokudubula okuphindaphindiweyo kokukhanya, kwaye kwangaxeshanye, ukugqabhuka kokukhanya okuninzi kwamasuntswana e-melanin. kuqhutywa, Inokwenza amasuntswana e-melanin abe mancinci kwaye alungele ukuginywa kwaye akhutshwe ngumzimba.
Su Bifeng et al.i-chloasma iphathwe nge-PRP isitofu sokukhanya samanzi esidibeneyo kunye ne-Q switched Nd: YAG 1064nm laser.Phakathi kwezigulane ze-100 ezine-chloasma, izigulane ze-15 kwiqela le-PRP + le-laser zaphiliswa ngokusisiseko, izigulane ze-22 zaphuculwa kakhulu, izigulane ze-11 zaphuculwa, kwaye isigulane se-1 sasingasebenzi;Kwiqela le-laser kuphela, iimeko ezi-8 zanyangwa ngokusisiseko, iimeko ze-21 zazisebenza ngokuphawulekayo, iimeko ze-18 zaphuculwa, kwaye iimeko ezi-3 zazingasebenzi.Umahluko phakathi kwamaqela amabini wawubalulekile ngokwezibalo (P <0.05).U-Peng Guokai kunye neNgoma yeJiquan baqinisekisa ngakumbi ukusebenza kwe-Q-switched laser edityaniswe ne-PRP kunyango lwe-chloasma yobuso.Iziphumo zibonise ukuba i-Q-switched laser edibeneyo ne-PRP yayisebenza kakuhle kunyango lwe-chloasma yobuso
Ngokophando lwangoku kwi-PRP kwi-pigmented dermatoses, indlela enokwenzeka ngayo ye-PRP kunyango lwe-chloasma kukuba i-PRP yandisa i-TGF yezilonda zesikhumba- β Ukubonakaliswa kweprotheni kunokuphucula izigulane ze-melasma.Ukuphuculwa kwe-PRP kwizilonda zesikhumba ze-vitiligo zezigulane zinokunxulumana ne-α i-adhesion molecules ezifihliweyo ngeegranules zihambelana nokuphuculwa kwe-microenvironment yendawo yezilonda ze-vitiligo ngama-cytokines.Ukuqala kwe-vitiligo kuhambelana ngokusondeleyo nokungakhuseleki okungaqhelekanga kwezilonda zesikhumba.Uphononongo lufumene ukuba ukungahambi kakuhle kwamajoni omzimba kwizigulana ze-vitiligo kuhambelana nokungaphumeleli kwe-keratinocytes kunye ne-melanocytes kwizilonda zolusu ukumelana nomonakalo we-melanocytes obangelwa zizinto ezahlukeneyo zokudumba kunye nee-chemokines ezikhutshwe kwinkqubo yoxinzelelo lwe-intracellular oxidative.Nangona kunjalo, izinto ezahlukeneyo zokukhula kweplatelet ezifihliweyo yi-PRP kunye neentlobo ngeentlobo ze-cytokines ezichasayo ezikhutshwe ziiplatelet, ezifana ne-soluble tumor necrosis factor receptor I, IL-4 kunye ne-IL-10, ezichasene ne-interleukin-1 receptor, dlala indima ethile ekulawuleni ulungelelwaniso lomzimba lwasekuhlaleni lwezilonda zesikhumba.
(Imixholo yeli nqaku ishicilelwe, kwaye asiboneleli nasiphi na isiqinisekiso esicacileyo okanye esichaziweyo sokuchaneka, ukuthembeka okanye ukugqibelela kokuqulathwe kweli nqaku, kwaye abanaxanduva ngezimvo zeli nqaku, nceda uqonde.)
Ixesha lokuposa: Nov-24-2022