I-Platelet Rich Plasma (PRP)
I-PRP iye yatsala ingqalelo kuba iqulethe izinto ezahlukeneyo zokukhula, kwaye isetyenziswa ngokubanzi kwi-maxillofacial surgery, i-orthopedics, utyando lweplastiki, i-ophthalmology kunye nezinye iinkalo.Kwi-2006, u-Uebel et al.okokuqala wazama ukubuyisela iiyunithi ze-follicular ukuba zitshintshwe nge-PRP kwaye zaqaphela ukuba xa kuthelekiswa nommandla wokulawula i-scalp, indawo yokufakelwa kweenwele ephathwayo ye-PRP yasinda kwiiyunithi ze-follicular ze-18.7 / cm2, ngelixa iqela lokulawula lisinda kwiiyunithi ze-follicular ze-16.4./ cm2, ukuxinana kunyuke nge-15.1%.Ngoko ke, kucingelwa ukuba izinto zokukhula ezikhutshwe ngamaplatelets zingenza kwiiseli ze-stem ze-hair follicle bulge, zikhuthaze ukuhlukana kweeseli ze-stem kunye nokukhuthaza ukubunjwa kwemithambo yegazi emitsha.
Ngo-2011, uTakikawa et al.isetyenziswe i-saline eqhelekileyo, i-PRP, i-heparin-protamine microparticles edibeneyo ne-PRP (PRP & D / P MPs) kwi-injection subcutaneous yezigulane ze-AGA ukuseta ulawulo.Iziphumo zibonise ukuba indawo enqamlezileyo yeenwele kwiqela le-PRP kunye neqela le-PRP & D/P leMPs yanda kakhulu, imicu ye-collagen kunye ne-fibroblasts kwi-follicles yeenwele zandiswa phantsi kwe-microscope, kunye nemithambo yegazi ejikeleze iifollicle zeenwele zanda.
I-PRP isisityebi kwizinto ezikhulayo zeplatelet.Ezi protheni ezibalulekileyo zilawula ukufuduka kweeseli, ukudibanisa, ukwanda, kunye nokwahlulahlula, ukukhuthaza ukuqokelela kwe-matrix ye-extracellular, kunye nezinto ezininzi zokukhula zikhuthaza ukukhula kweenwele: izinto zokukhula kwi-PRP zisebenzisana neenwele zeenwele.Ukudityaniswa kweeseli ze-stem ze-bulge kubangela ukwanda kweefollicles zeenwele, kuvelisa iiyunithi ze-follicular, kwaye kukhuthaze ukuvuselelwa kweenwele.Ukongeza, inokuthi isebenze ukusabela kwe-cascade esezantsi kwaye ikhuthaze i-angiogenesis.
Ubume bangoku be-PRP kuNyango lwe-AGA
Akukho mvumelwano malunga nendlela yokulungiselela kunye ne-platelet enrichment factor ye-PRP;iirejimeni zonyango ziyahluka kwinani lonyango, ixesha lekhefu, ixesha lonyango, indlela yokutofa, kunye nokuba amayeza adibeneyo asetyenziswayo.
UMapar et al.zibandakanya izigulane ze-17 zesilisa kunye nesigaba se-IV ukuya kwi-VI (indlela yokumisa i-Hamilton-Norwood), kwaye iziphumo zibonise ukuba akukho mahluko phakathi kwe-PRP kunye ne-placebo injections, kodwa uphando lwenziwa kuphela ii-injection ze-2, kwaye inani lonyango lincinci kakhulu.Iziphumo zivulelekile ukuba zibuze.;
I-Gkini et al ifumene ukuba izigulane ezinesigaba esisezantsi zibonise ukuphendula okuphezulu kunyango lwe-PRP;lo mbono waqinisekiswa ngu-Qu et al, obandakanya izigulane ze-51 zamadoda kunye ne-42 yabasetyhini abanenqanaba le-II-V kumadoda kunye nam kubasetyhini ~ Inqanaba le-III (i-staging yi-Hamilton-Norwood kunye ne-Ludwig indlela yokumisa), iziphumo zibonisa ukuba unyango lwe-PRP ulwahlulo oluphawulekayo lwezibalo kwizigulane ezinezigaba ezahlukeneyo zamadoda nabasetyhini, kodwa ukusebenza kwenqanaba eliphantsi kunye nenqanaba eliphezulu lingcono, ngoko ke abaphandi bancoma i-II, iSigaba se-III izigulane zesilisa kunye nesigaba I izigulane zabasetyhini ziphathwe nge-PRP.
IFactor yokuNtyebisa esebenzayo
Ukwahluka kweendlela zokulungiselela i-PRP kwisifundo ngasinye kwakhokelela kwiifolda ezahlukeneyo zokutyebisa ze-PRP kwisifundo ngasinye, ezininzi zazo zigxininiswe phakathi kwe-2 kunye ne-6 amaxesha.I-Platelet degranulation ikhupha inani elikhulu lezinto zokukhula, ilawula ukufuduka kweeseli, ukunamathisela, ukwanda kunye nokwahlulahlula, ivuselela ukwanda kwe-follicle cell cell, i-tissue vascularization, kwaye ikhuthaza ukuqokelela kwe-matrix ye-extracellular.Ngelo xesha, indlela ye-microneedling kunye ne-low-energy laser therapy ithathwa njengento Ivelisa umonakalo wezicubu ezilawulwayo kwaye ivuselela inkqubo ye-platelet degranulation yendalo, emisela umgangatho wemveliso ye-PRP kuxhomekeke kumsebenzi wayo we-biological.Ke ngoko, kubalulekile ukuphonononga uxinzelelo olusebenzayo lwe-PRP.Olunye uphando lukholelwa ukuba i-PRP ene-fold enrichment of 1-3 times is more effective than a high enrichment fold, kodwa Ayatollahi et al.isetyenziswe i-PRP kunye ne-concentration concentration yamaxesha e-1.6 yonyango, kwaye iziphumo zibonise ukuba unyango lwezigulane ze-AGA lwalungasebenzi, kwaye lukholelwa ukuba i-PRP Ugxininiso olusebenzayo kufuneka lube ngamaxesha e-4 ~ 7.
Inani loNyango, iXesha leThuba kunye nexesha loNyango
Izifundo zikaMapar et al.kunye noPuig et al.bobabini bafumana iziphumo ezibi.Inani lezonyango ze-PRP kule mibini iprothokholi yokufunda yayiyi-1 kunye namaxesha e-2, ngokulandelanayo, eyayiphantsi kunezinye izifundo (uninzi lwe-3-6 amaxesha).UPicard et al.bafumanisa ukuba ukusebenza kwe-PRP kufikelele kwincopho yayo emva kwe-3 kwi-5 yonyango, ngoko bakholelwa ukuba ngaphezu kwe-3 unyango lunokufuneka ukuphucula iimpawu zokulahleka kweenwele.
Uhlalutyo lweGupta kunye neCarviel lufumene ukuba uninzi lwezifundo ezikhoyo zinexesha lonyango lwenyanga ye-1, kwaye ngenxa yenani elilinganiselweyo lezifundo, iziphumo zonyango ngeenaliti zenyanga ze-PRP azizange zithelekiswe kunye nezinye iifrikhwensi zenaliti, ezifana ne-injection ye-PRP yeveki.
Uphononongo olwenziwa nguHausauer noJones [20] lubonise ukuba izifundo ezifumana ii-injection zenyanga zinenkqubela enkulu kwinani leenwele xa kuthelekiswa nokuphindaphinda kweejojo kwiinyanga ze-3 (P <0.001);Schiavone et al.[21] wagqiba ukuba, Unyango kufuneka luphindwe i-10 kwiinyanga ze-12 emva kokuphela kwekhosi yonyango;IiNtlanga et al.ilandelwe iminyaka eyi-2, ixesha elide lokulandelelana phakathi kwazo zonke izifundo, kwaye zafumanisa ukuba ezinye izigulane zibuyele kwiinyanga ze-12 (iimeko ze-4 / 20), kwaye kwizigulane ze-16 Iimpawu zichazwe ngakumbi kwiinyanga.
Ekulandeleni kukaSclafani, kwafunyaniswa ukuba ukusebenza kwezigulane kuncipha kakhulu kwiinyanga ezi-4 emva kokuphela kwekhosi yonyango.UPicard et al.ubhekiselele kwiziphumo kwaye unike iingcebiso zonyango oluhambelanayo: emva kwexesha eliqhelekileyo lonyango lwe-3 yenyanga ye-1, unyango kufuneka lwenziwe rhoqo ngamaxesha e-3.Unyango olunzulu lwenyanga.Nangona kunjalo, uSclafani akazange achaze umlinganiselo weplatelet enrichment yamalungiselelo asetyenziswe kwinkqubo yonyango.Kule sifundo, i-8-9 ml ye-platelet-rich matrix ye-fibrin amalungiselelo yalungiswa ukusuka kwi-18 ml yegazi le-peripheral (i-PRP ekhutshiweyo yongezwa kwi-tube ye-CaCl2 yokucoca, kwaye i-fibrin glue yafakwa kwi-fibrin glue. Isitofu ngaphambi kokubunjwa) , sikholelwa ukuba ukutyetyiswa kweeplatelet kolu lungiselelo kunokuba kude nokwaneleyo, kwaye ubungqina obuninzi bufunekayo ukuxhasa.
Indlela yokutofa
Uninzi lweendlela zokutofa yinaliti ye-intradermal kunye ne-subcutaneous injection.Abaphandi baxoxe ngempembelelo yendlela yokulawula kwisiphumo sonyango.UGupta kunye noCarviel bacebise inaliti engaphantsi kwesikhumba.Abanye abaphandi basebenzisa inaliti ye-intradermal.I-injection ye-Intradermal inokulibazisa ukungena kwe-PRP egazini, ukunciphisa izinga le-metabolic, ukwandisa ixesha lesenzo sendawo, kunye nokwandisa ukuvuselela i-dermis ukukhuthaza ukukhula kweenwele.nobunzulu abufani.Sincoma ukuba ubuchule benaliti ye-Nappage kufuneka isetyenziswe ngokungqongqo xa kusenziwa iinaliti ze-intradermal ukungabandakanyi impembelelo yokwahlukana kwenaliti, kwaye sincoma ukuba abaguli bachebe iinwele zabo zibe mfutshane ukujonga indlela yeenwele, kwaye bahlengahlengise i-angle yokufaka inaliti ngokufanelekileyo ngokwendlela yayo. isalathiso sokukhula ukwenzela ukuba incam yenaliti ikwazi ukufikelela ngeenxa zonke kwi-follicle yeenwele, ngaloo ndlela ikhulise i-PRP yoxinzelelo lwendawo kwi-follicle yeenwele.Ezi ngcebiso malunga neendlela zokutofa zezereferensi kuphela, njengoko kungekho zifundo zithelekiseka ngokuthe ngqo iingenelo kunye nobubi beendlela ezahlukeneyo zokutofa.
Unyango oludibeneyo
Jha et al.isetyenziswe i-PRP edibeneyo kunye ne-microneedling kunye ne-5% yonyango edibeneyo ye-minoxidil ukubonisa ukusebenza kakuhle kubungqina obunenjongo kunye nokuzivavanya kwesigulane.Sisajongene nemingeni ekumiseleni iirejimeni zonyango kwi-PRP.Nangona uninzi lwezifundo zisebenzisa iindlela ezisemgangathweni kunye nenani lokuvavanya ukuphuculwa kweempawu emva kokunyanga, njengokubalwa kweenwele ze-terminal, ukubala kweenwele ze-vellus, ukubalwa kweenwele, ubuninzi, ubukhulu, njl., iindlela zokuvavanya ziyahluka ngokubanzi;ukongeza, ukulungiswa kwe-PRP Akukho mgangatho ofanayo ngokwemigaqo yendlela, ukongeza i-activator, ixesha le-centrifugation kunye nesantya, ukugxilwa kweplatelet, njl.;iirejimeni zonyango ziyahluka kwinani lonyango, ixesha lekhefu, ixesha lokubuyisela, indlela yokutofa, kunye nokuba ukudibanisa amayeza;ukukhethwa kweesampulu kuphononongo alukho ukucwangciswa ngokweminyaka yobudala, isini, kunye nenqanaba le-alopecia ngakumbi kufiphaza uvavanyo lweziphumo zonyango lwe-PRP.Kwixesha elizayo, iisampulu ezinkulu ezizilawulayo zisafuneka ukucacisa iiparamitha ezahlukeneyo zonyango, kwaye uhlalutyo olongezelelekileyo lwemiba efana nobudala besigulane, isini, kunye nenqanaba lokulahleka kweenwele lunokuphuculwa ngokuthe ngcembe.
(Imixholo yeli nqaku ishicilelwe, kwaye asiboneleli nasiphi na isiqinisekiso esicacileyo okanye esichaziweyo sokuchaneka, ukuthembeka okanye ukugqibelela kokuqulathwe kweli nqaku, kwaye abanaxanduva ngezimvo zeli nqaku, nceda uqonde.)
Ixesha lokuposa: Aug-02-2022