I-PRP yenza ngokuchithwa kwe-alpha granules kwiiplatelet, eziqulethe izinto ezininzi zokukhula.Imfihlo esebenzayo yale miba yokukhula iqalwa yinkqubo yokudibanisa igazi kwaye iqala phakathi kwemizuzu eyi-10 ye-coagulation.Ngaphezulu kwe-95% yeemeko zokukhula ezenziwe kwangaphambili zifihlwa kwiyure enye.Ngoko ke, i-PRP kufuneka ilungiswe kwimeko ye-anticoagulant kwaye kufuneka isetyenziswe kwi-grafts, i-flaps, okanye izilonda ngaphakathi kwe-10 imizuzu ye-clot.Izifundo ezingasebenzisi igazi elipheleleyo le-anticoagulated ayizizo izifundo ze-PRP eziyinyani kwaye ziyalahlekisa.
Njengoko iiplatelet zisebenza yinkqubo yokujika, izinto zokukhula zikhutshelwa kwiseli nge-membrane yeseli.Kule nkqubo, amasuntswana e-alpha adibanisa iimbumba zeeseli zeplatelet, kwaye izinto zokukhula kweprotheni zigqibezela imeko ye-bioactive ngokongeza i-histone kunye ne-carbohydrate side chain kwezi proteni.Ngaloo ndlela, iiplatelet ezonakaliswe okanye ezingasebenziyo ngonyango lwe-PRP azikhuseli izinto ezikhulayo ze-bioactive kwaye zingakhokelela kwiziphumo ezidumazayo.Izinto ezifihlakeleyo zokukhula zibopha ngokukhawuleza kumphezulu ongaphandle wenwebu yeeseli kwi-graft, i-flap, okanye inxeba nge-transmembrane receptors.
Uphononongo lubonise ukuba iiseli ze-mesenchymal stem cells, i-osteoblasts, i-fibroblasts, iiseli ze-endothelial, kunye neeseli ze-epidermal zivakalisa i-cell membrane receptors kwizinto zokukhula kwi-PRP.Ezi receptor ze-transmembrane zibangela ukuba kusebenze iiprotheyini ze-endo native zangaphakathi ezikhokelela ekubonakalisweni (ukuvulwa) kweendlela eziqhelekileyo zokulandelelanisa i-cell cell, ezifana nokwanda kweeseli, ukubunjwa kwe-matrix, ukubunjwa kwe-osteoid, i-collagen synthesis, njl.
Ukubaluleka kolu lwazi kukuba izinto zokukhula kwe-PRP azize zingene kwiseli okanye i-nucleus yayo, aziyiyo i-mutagenic, zikhawuleza ukuvuselela ukuphilisa okuqhelekileyo.Ngoko ke, i-PRP ayinakho ukubangela ukubunjwa kwe-tumor.
Emva kokuqhambuka kokuqala kwezinto ezinxulumene ne-PRP, iiplatelet zidibanisa kwaye zikhuphe izinto ezongezelelweyo zokukhula kwiintsuku ezi-7 eziseleyo zobomi bazo.Emva kokuba iiplatelet ziphelile kwaye zifile, iimacrophages ezifikelela kummandla ngokusebenzisa i-platelet-stimulated blood vessels zikhulela ngaphakathi ukuze zithathe indima yokulawula ukuphilisa amanxeba ngokufihla ezinye zezinto ezifanayo zokukhula kunye nezinye.Ngaloo ndlela, inani leeplatelet ezikwi-graft, inxeba, okanye ihlwili legazi elincanyathiselwe kwiflap limisela ukuba inxeba liphole ngokukhawuleza kangakanani na.I-PRP yongeza nje kwelo nani.
Zingaphi iiplatelet ezaneleyo?
Uphononongo lubonise ukuba ukwanda kunye nokwahlulwa kwe-MSCS yabantu abadala kuhambelana ngokuthe ngqo nokugxilwa kweplatelet.Babonise i-dose-response curves, ebonisa ukuba impendulo yeselula eyaneleyo kwi-concentration ye-platelet yaqala kuqala xa amaxesha amane ukuya kwamahlanu ukubalwa kweplatelet yokuqala kwafikelelwa.Uphononongo olufanayo lubonise ukuba ukonyuka koxinzelelo lweplatelet kukwaphucule ukwanda kwe-fibroblast kunye nohlobo lwemveliso ye-collagen ye-I, kwaye uninzi lwempendulo yayixhomekeke kwi-PH, kunye neyona mpendulo ilungileyo eyenzekayo kumanqanaba aneasidi ye-pH.
Ezi zifundo azibonisi kuphela imfuno yezixhobo zokugxininisa iiplatelet ezaneleyo, kodwa zikwachaza iziphumo eziphuculweyo zokuvuselela amathambo kunye neziphumo eziphuculweyo zezicubu ezithambileyo ezinxulumene ne-PRP.
Kuba uninzi lwabantu lune-baseline platelet count eyi-200,000±75,000 nge-μl, i-PRP platelet count yesigidi esi-1 nge-μl nganye elinganiselwa kwi-aliquots eqhelekileyo ye-6-ml iye yaba luphawu “lwe-PRP yonyango.”Okubalulekileyo, uphononongo lubonise ukuba oku kugxininiswa kweplatelet kufezekiswa xa amanqanaba onyango efikelelwa, ngaloo ndlela kukhulula izinto zokukhula.
(Imixholo yeli nqaku ishicilelwe, kwaye asiboneleli nasiphi na isiqinisekiso esicacileyo okanye esichaziweyo sokuchaneka, ukuthembeka okanye ukugqibelela kokuqulathwe kweli nqaku, kwaye abanaxanduva ngezimvo zeli nqaku, nceda uqonde.)
Ixesha lokuposa: Sep-01-2022