I-Platelet-Rich Plasma (PRP) ye-Androgenetic Alopecia (AGA)

I-Androgenic alopecia (AGA), olona hlobo luqhelekileyo lokulahleka kweenwele, luphazamiseko oluqhubekayo lokulahleka kweenwele oluqala ebusheni okanye emva kwexesha lokufikisa.Ukuxhaphaka kwamadoda kwilizwe lam malunga ne-21.3%, kwaye ukuxhaphaka kwabasetyhini malunga ne-6.0%.Nangona abanye abaphengululi baye bacebisa izikhokelo zokuxilongwa kunye nokunyangwa kwe-alopecia ye-androgenetic e-China kwixesha elidlulileyo, ngokukodwa kugxininise ekuxilongweni kunye nonyango lwe-AGA, kunye nezinye iindlela zonyango zinqongophele.Kwiminyaka yakutshanje, ngokugxininiswa kunyango lwe-AGA, ezinye iindlela zonyango olutsha ziye zavela.

I-Etiology kunye nePathogenesis

I-AGA sisifo semfuza esinaso sepolygenic recessive disorder.Uphando lwasekhaya lwe-epidemiological lubonisa ukuba i-53.3% -63.9% yezigulane ze-AGA zinembali yentsapho, kwaye umgca wooyise uphezulu kakhulu kunomgca womama.Ulandelelwano lwangoku lwe-genome kunye nezifundo zokwenza imephu zichonge iintlobo ezininzi zofuzo, kodwa iijini zabo ze-pathogenic azikachongwa.Uphando lwangoku lubonisa ukuba i-androgens idlala indima ebalulekileyo kwi-pathogenesis ye-AGA;ezinye izinto ezibandakanya ukudumba okujikeleze ifollicle yeenwele, ukwanda koxinzelelo kubomi, ukuxinezeleka kunye nokuxhalaba, kunye nokuphila kakubi kunye nokutya okungalunganga kunokuzenza mandundu iimpawu ze-AGA.I-Androgens emadodeni ikakhulu ivela kwi-testosterone ekhutshwe ngamastes;i-androgens kubasetyhini ikakhulu ivela kwi-synthesis ye-adrenal cortex kunye nexabiso elincinci lokukhuselwa kwi-ovari, i-androgens ubukhulu becala i-androstenediol, enokuthi ifakwe kwi-testosterone kunye ne-dihydrotestosterone.Nangona i-androgens yinto ephambili kwi-pathogenesis ye-AGA, amanqanaba ajikelezayo e-androgen phantse kuzo zonke izigulane ze-AGA zigcinwa kumanqanaba aqhelekileyo.Uphononongo lubonise ukuba umphumo we-androgens kwiintlobo zeenwele ezithintekayo zonyuka ngenxa yokunyuka kwe-androgen receptor gene expression kunye / okanye ukwanda kwentetho yohlobo lwe-II i-5α yokunciphisa i-reductase kwi-follicle yeenwele kwindawo ye-alopecia.Kwi-AGA, i-dermal component cell of susceptible hair follicles iqulethe uhlobo oluthile lwe-II 5α reductase, enokuguqula i-androgen testosterone ejikelezayo kwindawo egazini kwi-dihydrotestosterone ngokuzibophelela kwi-intracellular androgen receptor.Ukuqala uthotho lweempendulo ezikhokelela kwinkqubela encinci ye-miniaturization yeefollicle zeenwele kunye nokulahleka kweenwele ukuya kwinkqayi.

IiMbonakaliso zeklinikhi kunye neeNgcebiso zonyango

I-AGA luhlobo lwe-alopecia olungaqhawukiyo oludla ngokuqala ngexesha lokufikisa kwaye lubonakala ngokucutheka ngokuqhubekayo kwedayamitha yeenwele, ukulahleka kweenwele ezixineneyo, kunye ne-alopecia de kube ngamaqondo ahlukeneyo okuba nenkqayi, edla ngokukhatshwa ziimpawu zokunyuka kweoli yentloko.

Isicelo se-PRP

I-concentration yeplatelet ilingana ne-concentrate ye-4-6 amaxesha e-platelet concentration kwigazi elipheleleyo.Emva kokuba i-PRP ivuliwe, i-α granules kwiiplatelet iya kukhulula inani elikhulu lezinto zokukhula, ezibandakanya ukukhula kweplatelet-derived factor, ukuguqula ukukhula kwe-β, ukukhula kwe-insulin, ukukhula kwe-epidermal kunye ne-vascular endothelial growth factor, njl. yokukhuthaza ukukhula kwefollicle yeenwele, kodwa indlela ethile yokusebenza ayicacanga ngokupheleleyo.Ukusetyenziswa kukujova i-PRP kwindawo kwi-dermis layer ye-scalp kwindawo ye-alopecia, kanye ngenyanga, kunye ne-injection eqhubekayo i-3 ukuya kumaxesha e-6 inokubona umphumo othile.Nangona izifundo ezahlukeneyo zeklinikhi ekhaya nakwamanye amazwe ziye zaqinisekisa kwangaphambili ukuba i-PRP inempembelelo ethile kwi-AGA, akukho mgangatho ofanayo wokulungiselela i-PRP, ngoko ke izinga elisebenzayo lonyango lwe-PRP alufani, kwaye lunokusetyenziswa njengoncedo. kuthetha ukuba unyango lwe-AGA kweli nqanaba.

(Imixholo yeli nqaku ishicilelwe, kwaye asiboneleli nasiphi na isiqinisekiso esicacileyo okanye esichaziweyo sokuchaneka, ukuthembeka okanye ukugqibelela kokuqulathwe kweli nqaku, kwaye abanaxanduva ngezimvo zeli nqaku, nceda uqonde.)