I-Androgenic alopecia (AGA) luhlobo oluqhelekileyo lokulahleka kweenwele ezibangelwa lufuzo kunye namahomoni, abonakaliswe ngokuncipha kweenwele zentloko.Phakathi kweminyaka engama-60 ubudala, i-45% yamadoda kunye ne-35% yabasetyhini bajongene nengxaki ye-AGA.Iiprothokholi zonyango ezivunyiweyo ze-AGA ziquka i-finasteride yomlomo kunye ne-topical minoxidil.Okwangoku, ngenxa yokungabikho konyango olusebenzayo, i-PRP iye yaba yolunye unyango olutsha noluthembisayo.Inani elikhulu lezinto zokukhula kwi-PRP linokukhuthaza ukuvuselelwa kweenwele kunye neplatelet α Iindidi ezahlukeneyo zokukhula ezifihliweyo yi-granules isenzo kwiiseli ze-stem kwi-hair follicle bulge area kunye nokukhuthaza ukubunjwa kwemithambo yegazi emitsha.Nangona amanqaku amaninzi achaze oku, akukho protocol esemgangathweni yokulungiswa kwe-PRP, indlela yokulawula kunye novavanyo lweziphumo zeklinikhi.Eli nqaku lijolise ekuvavanyeni ukusebenza kwe-PRP kunyango lwe-AGA kunye nokuphonononga iindlela ezahlukeneyo zonyango ezikhoyo.
Indlela yokusebenza ye-PRP:
I-PRP ivuliwe emva kokuba ifakwe kwi-scalp ukukhulula inani elikhulu lezinto zokukhula kunye nokukhuthaza ukukhula kweenwele.Le miba yokukhula inokwenza i-fibroblasts isebenze, ikhuthaze i-collagen synthesis, iphucule i-extracellular matrix secretion kwaye ilawule ukubonakaliswa kwezinto ezingapheliyo zokukhula.Izinto zokukhula (PDGF, TGF- β, VEGF, EGF, IGF-1) inokukhuthaza ukwanda kweeseli kunye nokwahlula, iiseli ze-chemotactic stem, ukukhuthaza ukuphuhliswa kweenwele ezinde, kunye nokukhuthaza i-follicle angiogenesis yeenwele.Ezinye izinto (i-serotonin, i-histamine, i-dopamine, i-calcium kunye ne-adenosine) inokunyusa ukunyameka kwe-membrane kunye nokulawula ukuvutha.
Ulungiselelo lwe-PRP:
Zonke izicwangciso zokulungiselela i-PRP zilandela umgaqo oqhelekileyo, kunye ne-anticoagulants (ezifana ne-citrate) zongezwa kwigazi eliqokelelweyo ukuze kugwenywe i-coagulation ngokuzenzekelayo kunye nokusebenza kweplatelet.I-Centrifuge ukususa iiseli ezibomvu zegazi kunye nokugxila kwiiplatelet.Ukongeza, izikimu ezininzi zikhetha i-activators zeplatelet exogenous (ezifana ne-thrombin kunye ne-calcium chloride) ukukhuthaza ukukhululwa ngokukhawuleza kwezinto zokukhula kwiiplatelet ngendlela exhomekeke kwidosi.Iiplatelet ezingasebenziyo zinokuphinda zisebenze ngedermal collagen okanye i-autothrombin.Ngokubanzi, ukukhula okusebenzayo kufihlwa kwimizuzu eli-10 emva kokusebenza, kwaye i-95% ye-synthesized factor factor ikhutshwa kwiyure enye, ihlala iveki enye.
Isicwangciso sonyango kunye nokugxila:
I-PRP idla ngokutofwa ngaphantsi kwesikhumba okanye nge-intradermally.Okwangoku, i-frequency yonyango efanelekileyo kunye nekhefu ayikasekwa.Ukugxininiswa kwe-PRP yinto ebalulekileyo echaphazela umphumo wekliniki.Amanqaku asixhenxe afakiwe abeka phambili ukuba i-PRP igxininise kakhulu ngamaxesha e-2 ~ 6, kwaye ukugxininiswa okugqithisileyo kuya kuthintela i-angiogenesis.Kusekho impikiswano malunga nokuba iqulethe iiseli ezimhlophe zegazi.
Iziphumo zophando zangoku zibonisa ukubaI-PRP ingasetyenziselwa unyango lwe-AGA.Izifundo ezisixhenxe kwezilithoba zichaze iziphumo ezilungileyo.Ukusebenza kwe-PRP kwavavanywa kwiimbono ezininzi: indlela yokufumanisa i-PTG, uvavanyo lwe-tension yeenwele, ukubalwa kweenwele kunye nobuninzi beenwele, ixesha lokukhula ukuya kwixesha lokuphumla, kunye novavanyo lokwaneliseka kwesigulane.Ezinye izifundo zichaze kuphela umphumo wokuphucula ukulandelwa kweenyanga ze-3 emva kokunyanga kwe-PRP, kodwa kwakungekho iziphumo zokulandelelana kweenyanga ze-6.Ezinye izifundo zokulandelela ixesha elide (i-6 ukuya kwiinyanga ze-12) zichaze ukuhla kweenwele zeenwele, kodwa kwakusengaphezulu kunenqanaba lesiseko.Imiphumo emibi yachazwa kuphela njengentlungu engapheliyo kwindawo yokutofa.Akukho ziphumo zibi zichaziweyo.
Unyango olucetyiswayo:
Ekubeni i-PRP ayivimbeli inqanaba le-hormone ehambelana ne-AGA, kucetyiswa ukuba i-PRP isetyenziswe njengonyango lwe-adjuvant ye-AGA.Ngoko ke, izigulane kufuneka zikhuthazwe ukuba zigcine amayeza e-topical okanye ngomlomo (njenge-minoxidil, i-spironolactone kunye ne-finasteride).Ngokusekwe kolu phando lokubuyela emva, kucetyiswa ukuba ulungiselele i-P-PRP (i-leukopenia) kunye ne-concentration ye-3-6 amaxesha egazi elipheleleyo.Ukusetyenziswa kwe-activators (i-calcium chloride okanye i-calcium gluconate) ngaphambi kokuba unyango luncede ukukhulula izinto zokukhula.Kucetyiswa ukuba i-injection subcutaneous kufuneka iqhutywe ukusuka kwindawo eneenwele ezinqabileyo, kunye neenwele kunye nentloko, kunye neendawo zokujova kufuneka zihlulwe.Idosi yesitofu imiselwa ngokweemfuno zonyango.I-injection frequency ikhethwa kwikhosi yokuqala yonyango (kanye ngenyanga, kathathu xa iyonke, iinyanga ezintathu), kwaye kanye emva kweenyanga ezintathu, kathathu ngokupheleleyo (oko kukuthi, kanye ngoJuni, ngoSeptemba nangoDisemba ngokulandelelanayo).Ewe, emva kwekhosi yokuqala yonyango, kuyasebenza ukutshintsha ixesha lekhefu libe kanye kwiinyanga ezintandathu.Ngokuqhelekileyo, izigulane zamadoda nabasetyhini ziye zafumana iziphumo ezilungileyo ekukhuleni kwakhona kweenwele, ukwanda kweenwele kunye nomgangatho wokuphucula ubomi emva kokujova i-PRP ukunyanga i-AGA (Umfanekiso 1 kunye noMfanekiso 2).
Isiphelo:
Uphononongo lweziphumo ezininzi zophando lubonisa ukuba i-PRP iyathembisa kunyango lwe-AGA.Ngexesha elifanayo, unyango lwe-PRP lubonakala lukhuselekile kwaye lungaphantsi kwemiphumo emibi.Nangona kunjalo, kusekho ukungabikho kwendlela yokulungiselela i-PRP esemgangathweni, ugxininiso, i-injection scheme, i-dosage, njl. Ngoko ke, kunzima ukuvavanya ukusebenza kwekliniki ye-PRP.Ukuze uqhubele phambili ufunde umphumo we-PRP ekuvuseleleni iinwele kwi-AGA, ubungakanani besampulu enkulu yovavanyo olulawulwa ngokungahleliwe (qaphela i-injection frequency, i-PRP concentration, kunye nokufezekisa ukulandelwa kwexesha elide) kuyadingeka.
(Imixholo yeli nqaku ishicilelwe, kwaye asiboneleli nasiphi na isiqinisekiso esicacileyo okanye esichaziweyo sokuchaneka, ukuthembeka okanye ukugqibelela kokuqulathwe kweli nqaku, kwaye abanaxanduva ngezimvo zeli nqaku, nceda uqonde.)
Ixesha lokuposa: Dec-08-2022