Ukhuseleko lwe-PRP kunye nokuthembeka

Ithembeke kangakanani i-PRP?

I-PRP yenza ngokuchithwa kwee-particle ze-alpha kwiiplatelet, eziqulethe izinto ezithile zokukhula.I-PRP kufuneka ilungiswe kwimeko ye-anticoagulant kwaye kufuneka isetyenziswe kwi-grafts, i-flaps, okanye izilonda ngaphakathi kwemizuzu ye-10 ye-clot.

Njengoko iiplatelet zisebenza yinkqubo yokujika, izinto zokukhula zikhutshelwa kwiseli nge-membrane yeseli.Kule nkqubo, amasuntswana e-alpha adibanisa iimbumba zeeseli zeplatelet, kwaye izinto zokukhula kweprotheni zigqibezela imeko ye-bioactive ngokongeza i-histone kunye ne-carbohydrate side chain kwezi proteni.

Uphononongo lubonise ukuba iiseli ze-mesenchymal stem cells, i-osteoblasts, i-fibroblasts, iiseli ze-endothelial, kunye neeseli ze-epidermal zivakalisa i-cell membrane receptors kwizinto zokukhula kwi-PRP.Ezi receptor ze-transmembrane zibangela ukuba kusebenze iiprotheyini ze-endo native zangaphakathi ezikhokelela ekubonakalisweni (ukuvulwa) kweendlela eziqhelekileyo zokulandelelanisa i-cell cell, ezifana nokwanda kweeseli, ukubunjwa kwe-matrix, ukubunjwa kwe-osteoid, i-collagen synthesis, njl.

Ngaloo ndlela, izinto zokukhula ze-PRP azizange zingene kwiseli okanye i-nucleus yayo, aziyiyo i-mutagenic, zikhawuleza ukuvuselela ukuphulukiswa okuqhelekileyo.

Emva kokuqhambuka kokuqala kwezinto ezinxulumene ne-PRP, iiplatelet zidibanisa kwaye zikhuphe izinto ezongezelelweyo zokukhula kwiintsuku ezi-7 eziseleyo zobomi bazo.Emva kokuba iiplatelet ziphelile kwaye zifile, iimacrophages ezifikelela kummandla ngokusebenzisa i-platelet-stimulated blood vessels zikhulela ngaphakathi ukuze zithathe indima yokulawula ukuphilisa amanxeba ngokufihla ezinye zezinto ezifanayo zokukhula kunye nezinye.Ngaloo ndlela, inani leeplatelet ezikwi-graft, inxeba, okanye ihlwili legazi elincanyathiselwe kwiflap limisela ukuba inxeba liphole ngokukhawuleza kangakanani na.I-PRP yongeza nje kwelo nani.

I-1) i-PRP inokuphucula iiseli ze-bone progenitor kwi-host bone kunye ne-bone grafts kunye nokukhuthaza ukubunjwa kwamathambo.I-PRP iqulethe izinto ezahlukeneyo zokukhula, ezinokukhuthaza ukuhlukana kweeseli kunye nokwahlula kunye nokukhuthaza ukulungiswa komzimba.

I-2) I-leukocytes kwi-PRP inokuphucula amandla okuchasana nokusuleleka kwendawo eyenzakeleyo, incede umzimba ukuba ususe izicubu ze-necrotic, kwaye ukhawuleze ukulungiswa kokulimala.

I-3) i-PRP iqulethe inani elikhulu le-fibrin, enokwakha iqonga elingcono lokulungisa ukulungiswa komzimba kunye nokunciphisa amanxeba ngexesha elifanayo.

Ngaba i-PRP ikhuselekile kwaye isebenza ngokwenene?

1) Iimveliso zegazi ezizenzekelayo

Inani elikhulu leenkcukacha zovavanyo lubonise ukuba i-PRP ingabonisa ukhuseleko nokuthembeka kwayo kunyango oluninzi.Njengomveliso wegazi we-autologous, i-PRP igwema ngokufanelekileyo ukugatywa kunye nokudluliselwa kwezifo ezibangelwa ukusetyenziswa kwegazi le-allogeneic ngexesha lonyango.

2) Umqalisi we-Coagulation ukhuselekile

I-PRP isebenzisa i-thrombin ye-bovine njenge-coagulation initiator, eyenza ukutsalwa kwe-PRP ngaxeshanye kunye neenkqubo zotyando.I-thrombin yenkomo esetyenzisiweyo ilungiswa ngobushushu kwaye ayibangeli usulelo.Kwaye ngenxa yokuba inani le-thrombin yenkomo esetyenzisiweyo incinci kakhulu, ayingeni emzimbeni kwaye ibangele ukugatywa ngexesha lokusetyenziswa.

3) Imveliso ikhuselekile kwaye iyasebenza

Iindlela ze-Aseptic zisetyenziselwa ukulungiswa kwe-PRP, okubangela ukuba amahlule egazi angabangela iingxaki zokusuleleka kwaye azibangeli ukukhula kwebhaktheriya.

(Imixholo yeli nqaku ishicilelwe, kwaye asiboneleli nasiphi na isiqinisekiso esicacileyo okanye esichaziweyo sokuchaneka, ukuthembeka okanye ukugqibelela kokuqulathwe kweli nqaku, kwaye abanaxanduva ngezimvo zeli nqaku, nceda uqonde.)